Success Stories

"CORBEL aims to establish and support a new model for biological and medical research in Europe by harmonising user access, unifying data management, creating common ethical and legal services, and offering joint innovation support" - what does that mean in practice?

 

Learn from our Success Stories how we were able to help other researchers:

Greetings from the Sea – a CORBEL Open Call user reports about her first visit

Prof. Simona Candiani from the University of Genoa is one of our successful applicants, who were selected with her project in the 1st CORBEL Open Call. Her scientific interest addresses certain genes that might play an important role in evolutionary neural development. For her research, she uses amphioxus as a model system.
Simona’s first visit in the framework of her CORBEL access brought her to the marine station at Banyuls-sur-mer, which is the only Mediterranean infrastructure that offers the possibility to collect amphioxus adult. She received training to perform in vitro fertilization of the collected animals to prepare embryo cultures, which will be needed for RNA extraction and whole mount in situ hybridization. “My stay in Banyuls was really useful as I had the opportunity to gain experience with amphioxus egg microinjection – a very challenging technique, as I was warned by several of my colleagues ahead of my trip! Nevertheless, I obtained a few microinjected animals and now I am looking forward to the next steps in my CORBEL project!”. Simona’s visit was facilitated a lot by the administrative support from CORBEL project managers and the technical assistance by local scientific staff.

As second service provider in her project pipeline, Simona requested access to the Advanced Light Microscopy Facility (ALMF) at EMBL Heidelberg. Here, she will receive not only access to the most advanced imaging technologies, but also technical support in developing a suitable imaging protocol. The goal is to reveal the 3D localization of several neural markers in amphioxus, which will eventually help to better characterize the function of the genes of interest in neural differentiation of amphioxus.

S. Candiani performing
amphioxus egg microinjection
model system amphioxus
research vessel Nereis

A framework for quality management in the biomedical research infrastructures

It has been widely recognized that the proper use of verified reference materials, standard operation protocols, study designs and data analysis and data storage is crucial to increase the quality of biomedical research and reduce the waste of resources that comes with irreproducible results.
The continuous development of community standards and references in the area of biomaterial and reagents, technology platforms, operations procedures, data collection and data processing is a core activity of the biomedical research infrastructures (BMS RIs) that are recognized as ESFRI Projects or ESFRI Landmarks.

In order to ensure that these standards are widely and consistently applied, the BMS RIs all endorse the methodologies and underlying mind set of quality management. They apply quality management systems that ensure that the resources and services that they offer to the European biomedical research community are of highest quality, produce reliable, traceable and reproducible outputs that are consistent across centers and are compliant with the regulatory environment.

The framework paper on QM can be downloaded here.

Assistance from the CORBEL Innovation Helpdesk

An SME company developing a novel product in the field of alleviating addiction requested assistance in identifying expertise centres to help clarify the mechanism of action of its investigational new drug substance and possibly enable smartly designed translational studies to establish in vivo efficacy.
A report was prepared listing a selection of academic groups of potential technical and clinical relevance. The SME studied this report of matching partners and is engaged in follow up contact with one of them to explore (under confidentiality) a potential collaboration.

Stay tuned for more success stories!

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This project receives funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 654248.