|Full name ||INFRAFRONTIER, the European research infrastructure for the development, phenotyping, archiving and distribution of mammalian models|
|Short name ||INFRAFRONTIER|
|Operational status||fully operational|
|Coordinating institution||INFRAFRONTIER GmbH|
Martin Hrabe de Angelis
|RI member countries ||AT, CA, CZ, DE, DK, ES, FI, FR, GR, IL, IT, NL, PT, SE, UK, EMBL|
info [at] infrafrontier.eu
All INFRAFRONTIER nodes and their resources and services can be accessed through the central INFRAFRONTIER web portal.
Description of the organisation
Europe urgently needs to find solutions for the grand challenges in the area of health. Different forms of cancer, metabolic diseases such as diabetes and obesity, chronic lung diseases, cardiovascular diseases, rare diseases, and infectious diseases are global threats to socio-economic well-being.
Mammalian models have proven to be a key resource for biomedical research to understand human diseases and to develop treatments for them. Mouse studies have been key to the six of the last 10 Nobel Awards in Medicine and Physiology and to breakthrough discoveries in the functional basis of human health and disease and are used in pre-clinical screening and drug development. The INFRAFRONTIER Research Infrastructure provides access to centralised high-quality resources and data for the development, phenotyping, archiving and distribution of mammalian models. Access is provided for individual researchers (bottom-up access) and for national, European and international research programmes (top-down access).
The INFRAFRONTIER Mouse Clinics offer access to a comprehensive first-line systemic phenotypic analysis covering a wide range of physiological functions ranging from cardiovascular, neuro-behaviour and metabolism expertise to detailed pathology assessments.
The nodes of the European Mouse Mutant Archive (EMMA) establish and manage a unified non-profit repository for maintaining medically relevant mouse mutants and making them available to the scientific community. EMMA is by far the largest mouse repository in Europe and the third-largest non-profit mouse archive worldwide. EMMA comprises over 5200 mutant mouse lines carrying targeted, transgenic, induced and other types of mutations.
INFRAFRONTIER also provides specialised services, training and consulting.
A list of services offered by INFRAFRONTIER can be downloaded here.