Bioinformatic and computational structural biology tools

Linking structural data with genomics and proteomics databases

Description
Often structural biology projects require to link structural data with genomics and proteomics databases. Scientists are supported with the annotations of 3D protein structures at residue level using proteomic and genomic sources including UniProt and ENSEMBL databases, diseases and genomic variants, protein domain families, disordered regions, short linear motifs and immunological epitopes.

Service provider
Instruct Image Processing Center (CSIC)

Location
Madrid, Spain

Contacts
Scientific contact: Carlos Oscar Sorzano Sanchez, Jose-Maria Carazo
Technical contact: Roberto Melero, Joan Segura

Support for preparation and calculation of 3D macromolecular maps

Description
The preparation and calculation of 3D macromolecular maps requires specialized software. Scientists can be supported in this work by full image processing of EM movies using the SCIPION package including particle picking, classification, volume reconstruction and atomic structure determination.

Service provider
Instruct Image Processing Center (CSIC)

Location
Madrid, Spain

Contacts
Scientific contact: Carlos Oscar Sorzano Sanchez, Jose-Maria Carazo
Technical contact: Roberto Melero, Joan Segura

Support in EM data acquisition planning

Description
The acquisition of high-quality data depends on careful planning prior to the actual experiment. Expert advice can be provided by the analysis of EM grids and the acquisition of EM movies through a FEI Talos Artica and a Falcon II direct detector.

Service provider
Instruct Image Processing Center (CSIC)

Location
Madrid, Spain

Contacts
Scientific contact: Carlos Oscar Sorzano Sanchez, Jose-Maria Carazo
Technical contact: Roberto Melero, Joan Segura

 

 

 

 

  

 

 

 

 

 

This project receives funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 654248.

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